RNF135 promotes the stemness of breast cancer cells by ubiquitinating and degrading DDX58
Overall, our results implied that RNF135 promotes the stemness of breast cancer cells by ubiquitinating and degrading DDX58 and targeting of RNF135/DDX58 axis might be a feasible method to suppress tumorigenesis and metastasis of breast cancer patients.
Authors
- Anqi Hu (ORCID: https://orcid.org/0000-0003-2675-1251)
- Baojiang Li (ORCID: https://orcid.org/0000-0002-7952-6691)
- Haifeng Li (ORCID: https://orcid.org/0000-0002-8883-9470)
- Lei Cao (ORCID: https://orcid.org/0000-0002-0443-2260)
- Riqing Huang (ORCID: https://orcid.org/0000-0003-3618-9311)
- Lin Zhang (ORCID: https://orcid.org/0000-0002-7515-5248)
- Xiaohong Zhou (ORCID: https://orcid.org/0000-0002-9878-7416)
- Yanxia Shi
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Taian City Central Hospital (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1016/j.tranon.2025.102321
- Citations
- 3
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Sun Yat-sen University Cancer Center