Early vascular aging ambulatory score in acute ischemic stroke
Understanding the impact of early vascular aging (EVA) on acute ischemic stroke (AIS) outcomes may provide new insights for improving prognostic assessments and developing targeted therapeutic strategies. This study aimed to validate the EVA ambulatory score (EVAAs) in AIS patients, assessing its association with stroke type, severity, and prognosis. Among the 2,730 AIS patients with a mean age of 72.0 ± 14.4 years, 83.4% exhibited EVA. EVA was identified as an independent predictor of poor outcome at both discharges (aOR:1.72, 95%CI:1.25-2.36, p < 0.001) and at 90 days (aOR:2.22, 95%CI:1.49-3.31, p < 0.001). In subgroup analyses, EVAAs showed improved predictive value in AIS patients with a lower cardiovascular disease burden and a non-atherogenic lipid profile. The EVAAs, as an indicator of EVA that could be easily integrated into daily clinical practice, are a significant predictor of adverse outcomes in AIS patients.
Authors
- Vasilios Kotsis (ORCID: https://orcid.org/0000-0002-3755-8097)
- Naohisa Hosomi (ORCID: https://orcid.org/0000-0001-7486-9700)
- Protazy Rejmer (ORCID: https://orcid.org/0000-0001-7454-5466)
- Thierry Guillaume (ORCID: https://orcid.org/0000-0001-5482-8565)
- Tomohisa Nezu (ORCID: https://orcid.org/0000-0003-4877-2336)
- Lisa Jane Woodhouse (ORCID: https://orcid.org/0000-0002-4472-1999)
- Davide Strambo (ORCID: https://orcid.org/0000-0003-4429-2714)
- Nikolaos Kakaletsis (ORCID: https://orcid.org/0000-0002-5263-1803)
- Eleni Korompoki (ORCID: https://orcid.org/0000-0003-0403-8316)
- Athanase D. Protogerou (ORCID: https://orcid.org/0000-0002-3825-532X)
- Wonjae Sung (ORCID: https://orcid.org/0000-0002-4637-5890)
- Christos Savopoulos (ORCID: https://orcid.org/0000-0002-7970-2464)
- Haralampos J Milionis (ORCID: https://orcid.org/0000-0003-3958-2266)
- Elpida Athanasopoulou (ORCID: https://orcid.org/0009-0009-6272-7102)
- Young Seo Kim (ORCID: https://orcid.org/0000-0002-7050-3426)
- George Ntaios (ORCID: https://orcid.org/0000-0002-0629-9248)
- Philip M. Bath (ORCID: https://orcid.org/0000-0003-2734-5132)
- Lauri Tulkki (ORCID: https://orcid.org/0000-0003-2823-8574)
- Matthias Hermann (ORCID: https://orcid.org/0000-0002-0694-7719)
- Maurizio Acampa (ORCID: https://orcid.org/0000-0003-4149-1785)
- Konstantinos Vemmos
- Patrik Michel
- Jukka Putaala
Institutions
- University of Siena (IT)
- Hiroshima University (JP)
- University of Helsinki (FI)
- University of Nottingham (GB)
- University of Thessaly (GR)
- University of Ioannina (GR)
- National and Kapodistrian University of Athens (GR)
- Aristotle University of Thessaloniki (GR)
- Helsinki University Hospital (FI)
- AHEPA University Hospital (GR)
- Centre Hospitalier Universitaire Vaudois (CH)
- Ospedale Santa Maria alle Scotte (IT)
- University Hospital of Zurich (CH)
- Papageorgiou General Hospital (GR)
- Alexandra Hospital (GR)
- University Hospital of Ioannina (GR)
- Hanyang University (KR)
- University of Lausanne (CH)
Publication Details
- Journal
- npj Aging
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1038/s41514-025-00202-7
- Citations
- 2
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 2.71