Complex of intratumoral mycobiome and bacteriome predicts the recurrence of laryngeal squamous cell carcinoma
Our results revealed that dysbiosis of intratumoral microbiota, including increased fungal community diversity and overgrowth of several fungal or bacterial organisms, is substantially linked to the recurrence of LSCC. Drinking habits might alter the laryngeal microbiota to influence the recurrence of LSCC. We also explored a method to potentially predict the recurrence of LSCC from a novel perspective. These findings could offer insights into the etiology of LSCC and pave way to prevent and treat LSCC.
Authors
- Feiran Li (ORCID: https://orcid.org/0000-0002-0407-6331)
- Hui‐Ching Lau (ORCID: https://orcid.org/0000-0002-6944-2507)
- Chi‐Yao Hsueh (ORCID: https://orcid.org/0000-0002-9679-7098)
- Huiying Huang (ORCID: https://orcid.org/0000-0002-5587-3576)
- Xiaohui Yuan (ORCID: https://orcid.org/0000-0001-5516-5919)
- Ming Zhang (ORCID: https://orcid.org/0000-0003-2909-8446)
- Zhenwei Wang (ORCID: https://orcid.org/0000-0001-7524-135X)
- Limin Zhao (ORCID: https://orcid.org/0000-0001-5623-8817)
- Xinhui Mao
Institutions
- Shanghai Jiao Tong University (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- Applied and Environmental Microbiology
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1128/aem.01954-24
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China