Human spindle-shaped urine-derived stem cell exosomes alleviate severe fatty liver ischemia–reperfusion injury by inhibiting ferroptosis via GPX4
SS-USCs possess strong tissue repair and antioxidant capabilities, primarily alleviating ferroptosis in the donor liver of fatty liver through the presence of GPX4 protein in their exosomes. This highlights SS-USCs as the most appropriate cell subtype for treating severe fatty liver IRI.
Authors
- Jinzhen Cai (ORCID: https://orcid.org/0000-0003-0752-2306)
- Xijian Huang
- Xinqiang Li
- Gui Fu (ORCID: https://orcid.org/0000-0001-8461-3717)
- Huan Liu (ORCID: https://orcid.org/0000-0003-0749-9118)
- Qingguo Xu (ORCID: https://orcid.org/0000-0003-3191-0771)
- Shangheng Shi (ORCID: https://orcid.org/0009-0006-2888-476X)
- Feng Wang (ORCID: https://orcid.org/0000-0002-4965-836X)
- Xinwei Li (ORCID: https://orcid.org/0000-0002-7036-5422)
- Muhammad Imran (ORCID: https://orcid.org/0000-0001-7882-5502)
- Ziyin Zhao (ORCID: https://orcid.org/0000-0002-7358-6124)
- Shuzhen Shi (ORCID: https://orcid.org/0000-0002-0841-4270)
- Meiying Song
- Cunle Zhu
Institutions
- Qingdao University (CN)
- Fujian Medical University (CN)
- ShanghaiTech University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s13287-025-04202-y
- Citations
- 9
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- National Natural Science Foundation of China