Exosomes from adipose-derived stem cells accelerate wound healing by increasing the release of IL-33 from macrophages
ADSC-Exos promote wound healing by regulating macrophage polarization and enhancing IL-33 release which drives keratinocyte proliferation, collagen deposition and epithelialization via the Wnt/β-catenin signaling pathway. These findings provide a mechanistic basis for the therapeutic potential of ADSC-Exos in tissue repair and regeneration.
Authors
- Chengfei Li (ORCID: https://orcid.org/0000-0002-1356-7466)
- Patrick P. Lin (ORCID: https://orcid.org/0000-0002-1460-4994)
- Boyuan Ren
- Xiao Xu (ORCID: https://orcid.org/0000-0002-1735-277X)
- Minliang Chen (ORCID: https://orcid.org/0000-0002-6413-5786)
- Hongfan Ding (ORCID: https://orcid.org/0000-0001-5165-0298)
- Qiang Li (ORCID: https://orcid.org/0000-0002-1990-8233)
- Ran Bai (ORCID: https://orcid.org/0000-0002-9107-3381)
- Yichen Wang (ORCID: https://orcid.org/0009-0009-9215-0463)
Institutions
- Chinese PLA General Hospital (CN)
- Beijing Radiation Center (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s13287-025-04203-x
- Citations
- 27
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 21.53
Funders
- National Natural Science Foundation of China