Huc-MSCs-derived exosomes alleviate non-alcoholic steatohepatitis by regulating macrophages polarization through miR-24-3p/STING axis
These findings suggest that the therapeutic effect of MSCs-exo on NASH may be attributed to the regulation of macrophage M2 polarization through miR-24-3p targeting STING. This provides a scientific basis for future clinical application.
Authors
- En‐Qiang Chen (ORCID: https://orcid.org/0000-0002-8523-1689)
- Shisheng Wang (ORCID: https://orcid.org/0000-0002-8720-0130)
- Changhai Liu (ORCID: https://orcid.org/0000-0002-0551-6482)
- Wei Jiang (ORCID: https://orcid.org/0000-0003-4414-595X)
- Dongbo Wu (ORCID: https://orcid.org/0000-0003-4500-047X)
- Hong Tang
- Ming Wang (ORCID: https://orcid.org/0000-0002-3821-7032)
- Lang Bai (ORCID: https://orcid.org/0000-0001-5042-4336)
- Yonghong Wang (ORCID: https://orcid.org/0000-0002-4756-2081)
- Taoyou Zhou
- Qingmin Zeng (ORCID: https://orcid.org/0000-0002-0775-9162)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- State Key Laboratory of Biotherapy
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s13287-025-04197-6
- Citations
- 12
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 9.67
Funders
- National Natural Science Foundation of China
- Sichuan University
- National Key Research and Development Program of China
- West China Hospital, Sichuan University