Investigating intestinal epithelium metabolic dysfunction in celiac disease using personalized genome-scale models
This study unveils new insights into the metabolic reprogramming of sIECs in CeD, highlighting specific dysregulated metabolic processes that compromise cellular functions essential for gut health. These findings offer a foundation for developing therapeutic interventions targeting impaired metabolic processes in CeD.
Authors
- Ali R. Zomorrodi (ORCID: https://orcid.org/0000-0002-9134-8082)
- Alessio Fasano (ORCID: https://orcid.org/0000-0002-2134-0261)
- Chloe V. McCreery (ORCID: https://orcid.org/0000-0001-5235-3527)
- Katarina Mollo
- Drew Alessi (ORCID: https://orcid.org/0009-0000-8215-3761)
Institutions
- University of Hawaiʻi at Mānoa (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- IIT@MIT (US)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s12916-025-03854-0
- Citations
- 3
- Primary Topic
- Celiac Disease Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 5.43