Human dental follicle stem cell-derived exosomes reduce root resorption by inhibiting periodontal ligament cell pyroptosis
DFSC-Exos downregulated NLRP3-mediated PDLC pyroptosis via miR-140-3p to block DNMT1/SOCS1/NFκB axis, which impacted M1 polarization and osteoclast formation, thereby alleviating RR.
Authors
- Xinyang Liu (ORCID: https://orcid.org/0000-0002-3083-5290)
- Ding Bai (ORCID: https://orcid.org/0000-0002-5058-4329)
- Xinyi Li (ORCID: https://orcid.org/0000-0002-6107-7066)
- Ping Zhang (ORCID: https://orcid.org/0000-0001-9163-6191)
- Song Chen (ORCID: https://orcid.org/0000-0001-7185-0123)
- J. Zhou (ORCID: https://orcid.org/0000-0001-8237-8274)
Institutions
- Sichuan University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s13287-025-04216-6
- Citations
- 9
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- China Postdoctoral Science Foundation
- Sichuan Province Science and Technology Support Program