Synthesis and Characterization of λ-Carrageenan Oligosaccharide-Based Nanoparticles: Applications in MRI and In Vivo Biodistribution Studies
λ-type carrageenan (λ-CAR) polysaccharides remain overlooked in the preparation of medical nanoparticles (NP) due to their unsuitable rheological properties and undesired biological effects, although they can also offer advantageous properties. To overcome these obstacles, oligosaccharide derivatives (λ-COS) have been successfully applied to the synthesis of stable NP incorporating both, ferrite cores and divalent manganese (Mn<sup>2+</sup>) releasable ions. The acute pro-inflammatory behavior and anticoagulant activity of native λ-CAR were significantly reduced in the case of λ-COS and λ-COS NP, rendering possible their use for medical applications. In vivo MRI studies in mice showed that the λ-COS NP framework is promising for two applications. The first is partial Mn<sup>2+</sup> release into the plasma to achieve intracellular Mn<sup>2+</sup>-based contrast of the myocardium and imaging of the hepatobiliary system. Second, it serves as a novel sugar-based coating that confers suitable pharmacokinetic properties to NP, making it promising for further targeted therapy applications.
Authors
- Hugo Groult (ORCID: https://orcid.org/0000-0002-1571-9400)
- Susana Carregal‐Romero (ORCID: https://orcid.org/0000-0003-1444-6268)
- Ainhize Urkola-Arsuaga
- David Castejón (ORCID: https://orcid.org/0000-0001-9080-7868)
- Armel Descamps‐Mandine (ORCID: https://orcid.org/0000-0003-3415-9338)
- Mathieu Ménard (ORCID: https://orcid.org/0000-0002-9439-4228)
- Chanez Manseur (ORCID: https://orcid.org/0009-0009-8499-0198)
- Benjamin Musnier (ORCID: https://orcid.org/0000-0001-7806-7000)
- Lydia Martínez‐Parra (ORCID: https://orcid.org/0000-0001-7348-6804)
- Jesús Ruı́z-Cabello (ORCID: https://orcid.org/0000-0001-8681-5056)
- Desirè Di Silvio (ORCID: https://orcid.org/0000-0002-7852-1055)
- Ameur El Amine Hamami (ORCID: https://orcid.org/0000-0002-5199-7600)
- Camille Daviaud
- Jennifer Saliba
- Ingrid Fruitier‐Arnaudin (ORCID: https://orcid.org/0000-0001-8993-1095)
- I. Orue
- Marc Jeannin
- Julien Cherfan
- Manon Porta-Zapata
- Axel Codault
- Claudia Beatriz Miranda Perez de Alejo
Institutions
- Ikerbasque (ES)
- Universidad Complutense de Madrid (ES)
- University of the Basque Country (ES)
- CIC biomaGUNE (ES)
- Boeing (Spain) (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Laboratoire des Sciences de l'Ingénieur pour l'Environnement (FR)
- Digital Research Alliance of Canada
- La Rochelle Université (FR)
Publication Details
- Journal
- Biomacromolecules
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1021/acs.biomac.4c01747
- Citations
- 2
- Primary Topic
- Seaweed-derived Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 4.55
Funders
- Fundación Ramón Areces
- Ministerio de Ciencia, Innovación y Universidades
- Agence Nationale de la Recherche
- Eusko Jaurlaritza
- Ikerbasque, Basque Foundation for Science
- Ligue Contre le Cancer
- Conseil Régional Aquitaine