HMGCL activates autophagy in osteosarcoma through β-HB mediated inhibition of the PI3K/AKT/mTOR signaling pathway
HMGCL inhibits the activation of the PI3K/AKT/mTOR signaling pathway mediated by β-HB, thereby reducing the proliferation, migration, and invasion of osteosarcoma cells while promoting autophagy. HMGCL may represent a new target for the treatment of osteosarcoma, offering new hope for patients with this disease.
Authors
- Kezhou Xia
- Wenda Liu
- Zhun Wei (ORCID: https://orcid.org/0000-0002-8699-3749)
- Weichun Guo (ORCID: https://orcid.org/0000-0001-8991-6362)
- Zicheng Wei (ORCID: https://orcid.org/0000-0003-2909-3290)
- Xinghan Huang
- Xiong Chen (ORCID: https://orcid.org/0009-0004-5620-6785)
- Xingyu Wang (ORCID: https://orcid.org/0000-0003-2247-3792)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s12967-025-06227-6
- Citations
- 6
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 8.13