Monocytic myeloid-derived suppressor cells contribute to the exacerbation of bone destruction in periodontitis
In conclusion, this study highlights the pivotal proinflammatory role of M-MDSCs in PD and suggests that targeting these cells may represent a novel immunotherapeutic approach. Future research could focus on strategies to specifically target MDSCs for the treatment of periodontitis.
Authors
- Wenchuan Li (ORCID: https://orcid.org/0000-0002-4495-9112)
- Zhengmei Lin (ORCID: https://orcid.org/0000-0003-1586-3741)
- Chi Zhan (ORCID: https://orcid.org/0000-0002-7592-7981)
- Zhi Song (ORCID: https://orcid.org/0000-0003-3742-0570)
- Zhaocai Zhou (ORCID: https://orcid.org/0000-0002-5441-3922)
- Wenji Luo
- Yufeng Liu (ORCID: https://orcid.org/0000-0002-9472-9104)
- Feng He (ORCID: https://orcid.org/0000-0003-3207-1295)
- Yaguang Tian
Institutions
- Sun Yat-sen University (CN)
- Guangzhou First People's Hospital (CN)
- Hainan General Hospital (CN)
- Stomatology Hospital (CN)
- Hainan Medical University (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s12967-025-06214-x
- Citations
- 7
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Natural Science Foundation of Hainan Province