Unravelling physical and radiobiological effects of proton boron fusion reaction with anionic metallacarboranes ([o-COSAN]-) in breast cancer cells
The radiosensitizing effect of [o-COSAN]<sup>-</sup> by strategic cellular <sup>11</sup>B placement and proton irradiation intensifies the DNA damage, making the nucleus particularly susceptible and thus increasing the destructive capability of alpha-particles, generated in the nuclear fusion reaction, which may lead to increased cell mortality.
Authors
- Pedro M.P. Santos (ORCID: https://orcid.org/0000-0002-3363-0098)
- L.C. Alves (ORCID: https://orcid.org/0000-0001-5369-5019)
- Kai Nishimura (ORCID: https://orcid.org/0000-0002-6301-3445)
- Francesç Teixidor (ORCID: https://orcid.org/0000-0002-3010-2417)
- Clara Viñas
- Teresa Pinheiro (ORCID: https://orcid.org/0000-0002-1836-2603)
- Fernanda Marques (ORCID: https://orcid.org/0000-0001-8440-5299)
- Ana Belchior (ORCID: https://orcid.org/0000-0002-6010-0316)
- Hiroyuki Nakamura (ORCID: https://orcid.org/0000-0002-4511-2984)
- J.M. Sampaio (ORCID: https://orcid.org/0000-0003-4359-493X)
- Bianca C. Alves
- Edgar Mendes
- Francisco Megre
Institutions
- Tokyo Institute of Technology (JP)
- Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento (PT)
- University of Lisbon (PT)
- LIP - Laboratory of Instrumentation and Experimental Particle Physics (PT)
- Life Science Institute (JP)
- Institut de Ciència de Materials de Barcelona (ES)
- Institute for Biotechnology and Bioengineering (PT)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s13550-025-01199-6
- Citations
- 6
- Primary Topic
- Boron Compounds in Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 8.16
Funders
- Ministerio de Economía y Competitividad
- International Atomic Energy Agency
- Fundação para a Ciência e a Tecnologia