The glutathione-dependent neuroprotective activity of the blood-CSF barrier is inducible through the Nrf2 signaling pathway during postnatal development
This work shows that the glutathione-dependent detoxifying function of the blood-CSF barrier can be pharmacologically enhanced through the Nrf2 signaling pathway to better protect the neural fluid environment from drug and toxic accumulation during the neonatal period.
Authors
- Cindy Durand
- Anne Denuzière
- Jean‐François Ghersi‐Egea (ORCID: https://orcid.org/0000-0002-0181-4909)
- Nathalie Strazielle
- Élodie Saudrais
- Sandrine Blondel
- Karen Silva
- Emmanuel Rault
- Pascal Mein
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Centre de Recherche en Neurosciences de Lyon (FR)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s12987-025-00622-3
- Citations
- 1
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Fondation pour la Recherche Médicale