Neue Regulatoren des Mannose-6-Phosphat-abhängigen Proteintransportwegs
Abstract Intracellular sorting of most soluble lysosomal enzymes occurs by tagging with mannose 6-phosphate (M6P) residues in the Golgi apparatus allowing recognition by M6P-receptors and transport to lysosomes. GlcNAc-1-phosphotransferase (GNPT) catalyzes the first step in M6P-tagging. Although the M6P sorting pathway is well-studied and was thought to be completely understood, several novel regulators of GNPT localization and stabilization in the cis-Golgi apparatus have been recently identified.
Authors
- Zilei Chen (ORCID: https://orcid.org/0000-0003-2300-9211)
- Sabrina Jabs (ORCID: https://orcid.org/0000-0001-8065-8002)
- Anna La Rosa
Institutions
- Christian-Albrechts-Universität zu Kiel (DE)
Publication Details
- Journal
- BIOspektrum
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1007/s12268-025-2367-2
- Primary Topic
- Viral Infectious Diseases and Gene Expression in Insects
- Type
- article
- Field-Weighted Citation Impact
- 0.00