Designer-Mikroben für eine CO2-basierte Bioökonomie

Abstract Carbon dioxide (CO 2 ), a major contributor to climate change, holds promise as a resource for sustainable biotechnology. Advances in synthetic biology and metabolic engineering have enabled the creation/engineering of microorganisms that utilize CO 2 or CO 2 -derived C1 compounds, such as methanol and formate, as substrates for bioproduction. Key breakthroughs include the development of synthetic metabolic pathways, such as the reductive glycine pathway and Serine-Threonine Cycle. The engineering of these pathways was supported by growth-coupled selection and adaptive laboratory evolution for strain optimization. These innovations underscore the potential for a CO 2 -based bioeconomy, paving the way for sustainable alternatives to fossil-based processes.