Does Age Modify the Relation Between Genetic Predisposition to Glaucoma and Various Glaucoma Traits in the UK Biobank?
With increasing age, an mtGPRS was a better predictor of higher IOP and glaucoma prevalence. It is useful to consider chronological age with genetic information in designing glaucoma screening strategies.
Authors
- Louis R. Pasquale (ORCID: https://orcid.org/0000-0002-5835-3496)
- Jae H. Kang (ORCID: https://orcid.org/0000-0003-4812-0557)
- Keva Li (ORCID: https://orcid.org/0000-0001-5922-4955)
- Ayellet V. Segrè (ORCID: https://orcid.org/0000-0001-6806-5845)
- Hugues Aschard (ORCID: https://orcid.org/0000-0002-7554-6783)
- Nazlee Zebardast (ORCID: https://orcid.org/0000-0003-1763-9401)
- Anthony P. Khawaja (ORCID: https://orcid.org/0000-0001-6802-8585)
- David Steven Friedman (ORCID: https://orcid.org/0000-0002-2055-5797)
- Ron Do (ORCID: https://orcid.org/0000-0002-3144-3627)
- Janey L. Wiggs (ORCID: https://orcid.org/0000-0003-1890-3278)
- Jihye Kim (ORCID: https://orcid.org/0000-0001-7096-820X)
- Huijuan Zhao (ORCID: https://orcid.org/0000-0001-6738-1141)
Institutions
- Brigham and Women's Hospital (US)
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- Moorfields Eye Hospital (GB)
- University College London (GB)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1167/iovs.66.2.57
- Citations
- 3
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.12
Funders
- Research to Prevent Blindness
- Pfizer
- National Institute for Health and Care Research
- Lister Institute of Preventive Medicine
- Santen
- Heidelberg Engineering
- Moorfields Eye Hospital NHS Foundation Trust
- National Institutes of Health
- Genentech
- Allergan
- National Eye Institute
- National Institute of General Medical Sciences
- Alcon Research Institute