Antibiotic treatment and survival in patients with resected, early-stage pancreatic ductal adenocarcinoma receiving chemotherapy
Antibiotic treatment in the 1 month following adjuvant gemcitabine initiation was associated with improved survival. These findings provide additional support for the hypothesis that antibiotic treatment may alter the pancreatic microbiome in a manner that reduces chemoresistance, potentially improving pancreatic ductal adenocarcinoma outcomes.
Authors
- Aimee L. Lucas (ORCID: https://orcid.org/0000-0003-0341-4826)
- Daniel J. Fulop (ORCID: https://orcid.org/0000-0003-1964-4861)
- Deirdre Jill Cohen (ORCID: https://orcid.org/0000-0002-6178-9266)
- Keith Magnus Sigel (ORCID: https://orcid.org/0000-0002-4051-4861)
- Joyce Serebrenik
- Arielle J. Labiner
- Emma W. Gong
Institutions
- George Washington University (US)
- Massachusetts General Hospital (US)
- Tisch Hospital (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JNCI Cancer Spectrum
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1093/jncics/pkaf024
- Citations
- 3
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 3.14