Perioperative clinical and radiological predictors of late post‐traumatic seizures in surgically treated patients with depressed skull fractures: A prospective observational study
A history of immediate or early PTS and abnormal radiological findings such as absent basal cisterns, MLS ≥ 5 mm, and dural tear are strong predictors of late PTS in DSF patients. The risk of developing late PTS gradually increases over time. We recommend aggressive management of increased intracranial pressure during the acute phase of TBI and systematic antiseizure prophylaxis to potentially mitigate the risk of late PTS. We also emphasize the importance of implementing long-term management and surveillance strategies for high-risk patients.
Authors
- Jean-Pierre O. Kalala
- Edward Baert (ORCID: https://orcid.org/0000-0002-8409-6366)
- Fredrick Makumbi (ORCID: https://orcid.org/0000-0002-6460-7325)
- David Patrick Kateete (ORCID: https://orcid.org/0000-0001-8075-3069)
- Moses Galukande
- Stephen Cose (ORCID: https://orcid.org/0000-0002-5156-037X)
- Hervé Monka Lekuya (ORCID: https://orcid.org/0000-0003-1913-4378)
- Jelle Vandersteene (ORCID: https://orcid.org/0000-0003-0438-5406)
Institutions
- Ghent University Hospital (BE)
- Makerere University (UG)
- Uganda Virus Research Institute (UG)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1111/epi.18300
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council
- Bijzonder Onderzoeksfonds UGent