Exposure of A2E to blue light promotes ferroptosis in the retinal pigment epithelium
Our results suggest the importance of blue light in A2E-mediated ferroptosis in the RPE, and deeply broaden the understanding of mechanisms underlying RPE atrophy arising from lipofuscin accumulation in STGD1 and dry AMD.
Authors
- Kunhuan Yang
- Yalin Wu (ORCID: https://orcid.org/0000-0001-5906-5675)
- Qingjian Li (ORCID: https://orcid.org/0000-0002-4495-6253)
- Shiying Li (ORCID: https://orcid.org/0000-0001-9783-9520)
- Yuling Chen (ORCID: https://orcid.org/0000-0002-8399-2070)
- Bo Yang (ORCID: https://orcid.org/0000-0003-0163-5879)
- Jingmeng Chen
Institutions
- Shenzhen University (CN)
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s11658-025-00700-2
- Citations
- 23
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 34.92
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- National Key Research and Development Program of China