Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis
The levels of GDF15 were elevated in the brains of septic mice. Targeting GDF15 with an anti-GDF15 antibody was found to improve sepsis-induced cognitive and memory impairment by reducing the microglial inflammatory response and phagocytosis. These results indicate that GDF15 could serve as an important therapeutic target for treating SAE.
Authors
- Shiyuan Luo
- Yan Luo (ORCID: https://orcid.org/0000-0002-5262-4363)
- Qianzi Yang (ORCID: https://orcid.org/0000-0003-2240-3356)
- Lijiao Chen (ORCID: https://orcid.org/0000-0002-1892-4119)
- Ying Wang (ORCID: https://orcid.org/0000-0002-1407-2668)
- Ting Liu (ORCID: https://orcid.org/0000-0003-1816-5551)
- Hongjun Huang (ORCID: https://orcid.org/0009-0006-5378-316X)
- Yifan Song (ORCID: https://orcid.org/0000-0002-0512-7153)
- Z. Shuai
Institutions
- Weifang Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s12974-025-03369-8
- Citations
- 20
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 33.36
Funders
- National Natural Science Foundation of China