Mesenchymal stem cell-derived small extracellular vesicles as a delivery vehicle of oncolytic reovirus
This study demonstrates that sEVs-reo can address key challenges associated with oncolytic virotherapy. These findings support potential of sEVs as a novel and effective DDS for reovirus in colon cancer treatment, while offering a versatile platform to enhance the efficacy of other oncolytic viruses.
Authors
- Naomi Sugimura (ORCID: https://orcid.org/0000-0001-8658-1755)
- Keiji Ozeki
- Shigeki Fukusada (ORCID: https://orcid.org/0000-0001-6540-8742)
- Yuki Kojima (ORCID: https://orcid.org/0000-0002-1558-5510)
- Hiromi Kataoka (ORCID: https://orcid.org/0000-0001-9491-0723)
- Mamoru Tanaka (ORCID: https://orcid.org/0000-0002-1782-4271)
- Ruriko Nishigaki
- Takaya Shimura (ORCID: https://orcid.org/0000-0002-6048-0021)
- Eiji Kubota (ORCID: https://orcid.org/0000-0002-6694-8772)
- Randal N. Johnston (ORCID: https://orcid.org/0000-0002-0599-6877)
- Konomu Uno (ORCID: https://orcid.org/0009-0006-2164-5205)
- Yoshinori Mori (ORCID: https://orcid.org/0000-0001-7199-4901)
- Makiko Sasaki (ORCID: https://orcid.org/0000-0002-4196-7766)
- Takuya Kanno
Institutions
- University of Calgary (CA)
- Nagoya City University (JP)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1016/j.lfs.2025.123489
- Citations
- 3
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Japan Society for the Promotion of Science