Seizures May Worsen Outcomes of Neonatal Hypoxic-Ischemic Encephalopathy: A Longitudinal Serum Biomarkers Study
Tau and NF-L levels are higher in those neonates developing Sz. Although relationships with worse brain injury may be driven by the HIE severity itself, modeling shows Sz as the most important feature, providing support to the notion that Sz may worsen brain injury in neonates with HIE even after TH.
Authors
- Martin K. Stengelin (ORCID: https://orcid.org/0000-0002-7298-2213)
- Frances J. Northington (ORCID: https://orcid.org/0000-0003-4557-2646)
- Jacob N. Wohlstadter (ORCID: https://orcid.org/0009-0000-4467-6895)
- Aylin Tekes (ORCID: https://orcid.org/0000-0002-4078-1484)
- Charlamaine Parkinson
- Ernest M. Graham (ORCID: https://orcid.org/0000-0003-1362-7083)
- Catherine Demos (ORCID: https://orcid.org/0000-0003-3914-1954)
- Allen D. Everett (ORCID: https://orcid.org/0000-0002-5559-6708)
- Srishti Jayakumar (ORCID: https://orcid.org/0009-0002-0925-9353)
- Jordan R. Kuiper (ORCID: https://orcid.org/0000-0002-4285-1562)
- George B. Sigal (ORCID: https://orcid.org/0000-0001-7149-6400)
- Gwendolyn Gerner (ORCID: https://orcid.org/0000-0003-1627-2775)
- Raul Chavez‐Valdez (ORCID: https://orcid.org/0000-0002-0788-8028)
- Carl E. Stafstrom (ORCID: https://orcid.org/0000-0002-4432-2453)
- Alison Kilborn
- Hrishikesh Kambli
- Khyzer B. Aziz (ORCID: https://orcid.org/0000-0002-3519-6694)
- Christopher Campbell (ORCID: https://orcid.org/0000-0001-5928-0463)
Institutions
- Milken Institute (US)
- Johns Hopkins University (US)
- George Washington University (US)
- Johns Hopkins Medicine (US)
- Johns Hopkins Hospital (US)
- Meso Scale Discovery (United States) (US)
Publication Details
- Journal
- Pediatric Neurology
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1016/j.pediatrneurol.2025.02.008
- Citations
- 1
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Thomas Wilson Sanitarium For Children of Baltimore City
- National Heart, Lung, and Blood Institute
- National Institute of Neurological Disorders and Stroke