A systematic analysis of the joint effects of ganglion cells, lagged LGN cells, and intercortical inhibition on spatiotemporal processing and direction selectivity

Simple cells in the visual cortex process spatial as well as temporal information of the visual stream and enable the perception of motion information. Previous work suggests different mechanisms associated with direction selectivity, such as a temporal offset in thalamocortical input stream through lagged and non-lagged cells of the lateral geniculate nucleus (LGN), or solely from intercortical inhibition, or through a baseline selectivity provided by the thalamocortical connection tuned by intercortical inhibition. While there exists a large corpus of models for spatiotemporal receptive fields, the majority of them built-in the spatiotemporal dynamics by utilizing a combination of spatial and temporal functions and thus, do not explain the emergence of spatiotemporal dynamics on basis of network dynamics emerging in the retina and the LGN. In order to better comprehend the emergence of spatiotemporal processing and direction selectivity, we used a spiking neural network to implement the visual pathway from the retina to the primary visual cortex. By varying different functional parts in our network, we demonstrate how the direction selectivity of simple cells emerges through the interplay between two components: tuned intercortical inhibition and a temporal offset in the feedforward path through lagged LGN cells. In contrast to previous findings, our model simulations suggest an alternative dynamic between these two mechanisms: While intercortical inhibition alone leads to bidirectional selectivity, a temporal shift in the thalamocortical pathway breaks this symmetry in favor of one direction, leading to unidirectional selectivity.