Stellate ganglia block reduces airway hyperresponsiveness with modulates the IKK/NF-κB/IL-4/IL-5/IL-13 pathway
SGB effectively reduced AHR while down-regulating the expression of key genes in the IKK/NF-κB/IL-4/IL-5/IL-13 signaling pathway, which may be related to IRE1β-mediated endoplasmic reticulum stress. However, further studies are needed to confirm the exact mechanism.
Authors
- Dong Yang (ORCID: https://orcid.org/0000-0002-9007-9909)
- Huiling Hu
- Haoyue Zhang (ORCID: https://orcid.org/0000-0002-9412-7584)
- Yan Zhou (ORCID: https://orcid.org/0000-0001-5385-1608)
- Qirui Duan (ORCID: https://orcid.org/0000-0003-3821-324X)
- Kaijun Zhao (ORCID: https://orcid.org/0000-0002-1001-4591)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- Beijing Jishuitan Hospital (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s12931-025-03131-x
- Citations
- 4
- Primary Topic
- Restless Legs Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 5.42