Burden of Comorbid Conditions Among Individuals Screened for Lung Cancer
This study found that the PLuS cohort members were older, had greater illness severity, and more racially and ethnically diverse than the NLST participants. Older patients and those with consequential comorbidity likely had different risk-benefit profiles, which may have affected screening outcomes. The high prevalence of multimorbidity, frailty, and impaired cardiopulmonary function in the PLuS cohort suggests that the balance of benefits and harms observed in the NLST group may not translate to the clinical setting.
Authors
- Christopher G. Slatore (ORCID: https://orcid.org/0000-0003-0958-8122)
- Jae Jeong Yang (ORCID: https://orcid.org/0000-0001-6370-2243)
- Shama D. Karanth (ORCID: https://orcid.org/0000-0001-5371-6908)
- Gerard A. Silvestri (ORCID: https://orcid.org/0000-0002-8464-2187)
- Michael K. Gould (ORCID: https://orcid.org/0000-0001-6749-8315)
- Martin C. Tammemägi (ORCID: https://orcid.org/0000-0002-4989-5058)
- Dejana Braithwaite (ORCID: https://orcid.org/0000-0003-2526-1197)
Institutions
- Kaiser Permanente (US)
- Medical University of South Carolina (US)
- Oregon Health & Science University (US)
- Brock University (CA)
- University of Florida Health (US)
- Portland VA Medical Center (US)
- University of Florida (US)
- VA Portland Health Care System (US)
- Florida College (US)
Publication Details
- Journal
- JAMA Health Forum
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1001/jamahealthforum.2024.5581
- Citations
- 7
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 10.63