Second-line drug resistance among multidrug-resistant tuberculosis patients in Ethiopia: A laboratory-based surveillance
Our study showed a prevalence of 2.35% for pre-XDR-TB and 1.07% for XDR-TB among MDR-TB cases, highlighting the importance of continuous surveillance and tailored treatment approaches to control the spread of drug-resistant TB (DR-TB) in Ethiopia. Future studies on MDR-TB surveillance should prioritize the integration of genomic surveillance into routine laboratory-based DR-TB monitoring systems to enhance early detection of resistance patterns, support targeted treatment strategies, and improve overall patient management efforts.
Authors
- Yeshiwork Abebaw (ORCID: https://orcid.org/0000-0001-6039-3430)
- Tegegn Belhu
- Ephrem Alemu
- Taye Letta
- Mesay Hailu Dangisso (ORCID: https://orcid.org/0000-0003-1245-8839)
- Biniyam Dagne (ORCID: https://orcid.org/0000-0002-5930-2690)
- Getu Diriba (ORCID: https://orcid.org/0000-0002-0166-682X)
- Melak Getu (ORCID: https://orcid.org/0000-0002-7650-0605)
- Getachew Seid (ORCID: https://orcid.org/0000-0002-8708-386X)
- Muluwork Getahun (ORCID: https://orcid.org/0000-0003-3407-983X)
- Amanuel Wondimu
- Bedo Buta
- Bazezew Yenew (ORCID: https://orcid.org/0000-0002-8505-7000)
- Michael Hailu
- Getachew Tollera (ORCID: https://orcid.org/0000-0002-5575-8439)
- Andargachew Kumsa
- Abyot Meaza (ORCID: https://orcid.org/0000-0002-8180-1816)
- Ayinalem Alemu (ORCID: https://orcid.org/0000-0001-5307-8774)
- Ashenafi Erresso
- Zigba Tefera
- Mengistu Tadesse (ORCID: https://orcid.org/0000-0001-9390-0355)
- Hilina Mollalign (ORCID: https://orcid.org/0000-0002-1918-0668)
- Betselot Zerihun Ayano
- Shewki Moga
- Gemechu Tadesse (ORCID: https://orcid.org/0009-0009-8417-1651)
- Minilik Demissie
- Saro Abdella
- Getachew Aga
Institutions
- Government of Ethiopia (ET)
- Ethiopian Public Health Institute (ET)
- Addis Ababa University (ET)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1016/j.jgar.2025.02.014
- Citations
- 6
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 8.38