Deficiency in nucleoside diphosphate kinase B leads to endothelial activation of the hexosamine biosynthesis pathway and cardiac dysfunction
Deficiency in NDPKB leads to endothelial activation of the HBP and cardiac dysfunction. Our findings may highlight the crucial role of proper endothelial HBP in maintaining cardiovascular homeostasis.
Authors
- Yuxi Feng (ORCID: https://orcid.org/0000-0002-4917-7283)
- Merve Keleş (ORCID: https://orcid.org/0000-0002-5212-3753)
- Abel Martín-Garrido
- Feng Shao (ORCID: https://orcid.org/0000-0002-4648-2493)
- Christiane Vettel (ORCID: https://orcid.org/0000-0002-4859-1183)
- Joerg Heineke (ORCID: https://orcid.org/0000-0002-1541-3030)
- Têmis Maria Félix (ORCID: https://orcid.org/0000-0002-8401-6821)
- Veronika Leiss
- Manuela Fuhrmann
- Santosh Lomada
- Zenghui Meng
- Johanna Wieland
- Yixin Wang (ORCID: https://orcid.org/0000-0002-6394-0214)
- Yi Hua Qiu (ORCID: https://orcid.org/0009-0007-5554-5998)
- Miao Qin
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- German Centre for Cardiovascular Research (DE)
- University Medical Centre Mannheim (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s12933-025-02633-8
- Citations
- 3
- Primary Topic
- Mechanisms of cancer metastasis
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Deutsche Forschungsgemeinschaft
- Universität Heidelberg