Renalase inhibition defends against acute and chronic β cell stress by regulating cell metabolism
Our work illustrates a role for Rnls in regulating cell metabolism. We show that inhibiting Rnls protects against chronic stress in vivo, and shields against acute stress in β cell lines in vitro by rewiring cell metabolism towards glycolysis.
Authors
- Yuki Ishikawa (ORCID: https://orcid.org/0000-0002-6514-8239)
- Susan Bonner‐Weir (ORCID: https://orcid.org/0000-0003-4682-0656)
- Tara MacDonald
- Siying Wei (ORCID: https://orcid.org/0009-0008-1500-1504)
- Stephan Kissler (ORCID: https://orcid.org/0000-0003-3062-7800)
- Jéssica Aparecida da Silva Pereira (ORCID: https://orcid.org/0000-0002-8503-1732)
- Birgitta Ryback (ORCID: https://orcid.org/0009-0006-7773-6878)
- Erica P. Cai (ORCID: https://orcid.org/0000-0003-2386-5747)
- Gordon C. Weir (ORCID: https://orcid.org/0000-0003-1456-0546)
- Meagan Arbeau
- Yi Peng (ORCID: https://orcid.org/0000-0001-7830-4694)
- Bryhan Mendez
Institutions
- Boston University (US)
- Joslin Diabetes Center (US)
- University of Toronto (CA)
- Dana-Farber Cancer Institute (US)
- Harvard Stem Cell Institute (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1016/j.molmet.2025.102115
- Citations
- 5
- Primary Topic
- Microbial metabolism and enzyme function
- Type
- article
- Field-Weighted Citation Impact
- 4.03