Activation of anti-donor CD8 alloimmune response in clinically diagnosed acute rejection early after living-donor lobar lung transplantation and its impact on outcome
Early lung graft infiltration after LDLLT increases the risk of the early development of CALD. Augmented anti-donor CD8 + response was also associated with graft infiltration, which could not be predicted from HLA mismatches but could be monitored using MLR in LDLLT.
Authors
- Hideki Ohdan (ORCID: https://orcid.org/0000-0002-9066-1288)
- Satona Tanaka (ORCID: https://orcid.org/0000-0002-0789-2350)
- Toyofumi Fengshi Chen-Yoshikawa (ORCID: https://orcid.org/0000-0003-0494-7077)
- Shigeto Nishikawa (ORCID: https://orcid.org/0000-0003-4485-2179)
- Hidenao Kayawake (ORCID: https://orcid.org/0000-0003-2357-7024)
- Masatsugu Hamaji (ORCID: https://orcid.org/0000-0002-9808-8260)
- Yojiro Yutaka (ORCID: https://orcid.org/0000-0003-4220-969X)
- Akihiro Ohsumi (ORCID: https://orcid.org/0000-0002-2847-9653)
- Hiroshi Date (ORCID: https://orcid.org/0000-0001-7262-6000)
- Naoki Tanimine (ORCID: https://orcid.org/0000-0003-2744-9097)
- Yoshito Yamada (ORCID: https://orcid.org/0000-0002-7659-8067)
- Daisuke Nakajima (ORCID: https://orcid.org/0000-0002-9761-2825)
- Koichiro Uchida (ORCID: https://orcid.org/0000-0003-0645-8373)
- Ichiro Sakanoue (ORCID: https://orcid.org/0000-0003-3903-6441)
- Yuka Tanaka (ORCID: https://orcid.org/0000-0001-9510-3421)
- Mamoru Takahashi (ORCID: https://orcid.org/0000-0001-6141-0554)
- Akiyoshi Nakakura
Institutions
- Hiroshima University (JP)
- Juntendo University (JP)
- Nagoya University Hospital (JP)
- Kyushu University Hospital (JP)
- Kyoto University Hospital (JP)
Publication Details
- Journal
- Transplant Immunology
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1016/j.trim.2025.102201
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science