Inverse relationship between circulating sphingosine-1-phosphate and precursor species and coronary artery calcification score in type 2 diabetes

This study unraveled that circulating S1P and their precursors are biomarkers of coronary atherosclerosis in T2D, which may underlie the lower abundance of S1P and anti-inflammatory activities of HDL. Trial registration ClinicalTrials.gov number, NCT02431234.

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Publication Details

Journal
Cardiovascular Diabetology
Published
2025-02-21
DOI
https://doi.org/10.1186/s12933-025-02624-9
Citations
3
Primary Topic
Sphingolipid Metabolism and Signaling
Type
article
Field-Weighted Citation Impact
2.42

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article

Inverse relationship between circulating sphingosine-1-phosphate and precursor species and coronary artery calcification score in type 2 diabetes

Maryse Guérin, Isabelle Guillas, Alban B. Redheuil, Sophie Tan et al.
3 citations
Cardiovascular Diabetology
Sphingolipid Metabolism and Signaling
2.42
article

Inverse relationship between circulating sphingosine-1-phosphate and precursor species and coronary artery calcification score in type 2 diabetes

Maryse Guérin, Isabelle Guillas, Alban B. Redheuil, Sophie Tan, Clément Materne, Éric Hajduch, Fabienne Foufelle, Hervé Le Stunff, Franck Phan, Sophie Galier, Olivier Bourron, Agnès Hartemann, Joe-elie Salem, Wilfried Le Goff
article en
3 citations

Abstract

This study unraveled that circulating S1P and their precursors are biomarkers of coronary atherosclerosis in T2D, which may underlie the lower abundance of S1P and anti-inflammatory activities of HDL. Trial registration ClinicalTrials.gov number, NCT02431234.

Cardiovascular DiabetologyVol. 24(1)
Centre National de la Recherche Scientifique (FR), Inserm (FR), Université Paris-Saclay (FR), Sorbonne Université (FR), Institut des Neurosciences Paris-Saclay (FR), Sorbonne Paris Cité (FR), Centre de Recherche des Cordeliers (FR), Assistance Publique – Hôpitaux de Paris (FR), Laboratoire d’Imagerie Biomédicale (FR), Fondation pour l’innovation en Cadiométabolisme et Nutrition (FR)
Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Assistance Publique - Hôpitaux de Paris, Fondation pour la Recherche Médicale, Fondation de France, Université de Bourgogne, Centre National de la Recherche Scientifique, Université Paris-Saclay, Assistance publique-Hôpitaux de Paris, Sorbonne Université
Good health and well-being
Openalex Percentile: Top 13%
Sphingolipid Metabolism and Signaling
2.42
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