Leptin Enhances M1 Macrophage Polarization and Impairs Tendon-Bone Healing in Rotator Cuff Repair: A Rat Model
Obesity and fatty infiltration of the rotator cuff muscle are associated with poor healing of rotator cuff tears. In this study, the effect of leptin, an adipose factor, on tendon-bone healing and the underlying mechanism were explored. Future studies might focus on developing novel approaches to improve the tendon-bone healing in patients with obesity by targeting leptin or the TNF signaling pathway with the aid of biomaterials.
Authors
- Xin Tang (ORCID: https://orcid.org/0000-0001-7577-5087)
- Duan Wang (ORCID: https://orcid.org/0000-0001-5487-4414)
- Yizhou Huang (ORCID: https://orcid.org/0000-0001-6606-2341)
- Lei Yao (ORCID: https://orcid.org/0000-0001-9546-8789)
- Kai Zhou (ORCID: https://orcid.org/0000-0001-7074-2956)
- Jian H. Li (ORCID: https://orcid.org/0000-0003-0376-0702)
- Tao Li (ORCID: https://orcid.org/0000-0002-5108-1774)
- Yinghao Li (ORCID: https://orcid.org/0000-0002-3234-8664)
- Long Pang
- Chunsen Zhang (ORCID: https://orcid.org/0000-0002-3741-400X)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Clinical Orthopaedics and Related Research
- Published
- 2025-02-19
- DOI
- https://doi.org/10.1097/corr.0000000000003428
- Citations
- 15
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 30.10
Funders
- National Natural Science Foundation of China
- West China Hospital, Sichuan University