The influence of b-lactam antibiotics on the excretion of aspartyl proteinaseb

-lactam antibiotics are bactericidal agents that have a monocyclic -lactam ring in their structure, which carries a secondary amino group and is responsible for antibacterial activity.They are the most used class of antibacterial agents in the fight against infectious diseases.However, the huge level of excessive use and abuse of antibiotics has led to the emergence of antimicrobial resistance, the collateral killing of commensal bacteria by broad-spectrum antibiotics as well as the emergence of invasive fungal infections caused by Candida albicans fungi, as the main cause of high morbidity and mortality in hospitalized and immunodeficient patients.Extracellular enzymes that are excreted by pathogens are involved in the spread of infection.Aspartyl proteinase is an extracellular enzyme that acts as one of the key determinants of the virulence of Candida albicans.The pathogenicity of the fungus also increases with increased secretion of the enzyme.Due to the constant increase in the number, severity and complications of invasive fungal infections, our primary goal was to investigate whether daily applied concentrations of certain -lactam antibiotics have the effect on the increased growth of the fungus Candida albicans as well as on the excretion of its virulence factor, the aspartyl proteinase.