Propranolol As an Anxiolytic to Reduce the Use of Sedatives for Critically Ill Adults Receiving Mechanical Ventilation (PROACTIVE): An Open-Label Randomized Controlled Trial
Propranolol is an inexpensive drug that effectively lowered the need for sedatives in critically ill patients managed in the COVID-19 pandemic. Propranolol may help preserve limited supplies of sedatives while achieving target sedation.
Authors
- Usman Saeed (ORCID: https://orcid.org/0000-0003-3418-9748)
- Rebecca Porteous (ORCID: https://orcid.org/0000-0003-2806-8974)
- Koby Anderson (ORCID: https://orcid.org/0000-0003-2514-9533)
- Sonia Himed (ORCID: https://orcid.org/0000-0002-1553-609X)
- Julie Lapenskie (ORCID: https://orcid.org/0000-0002-5358-5685)
- Salmaan Kanji (ORCID: https://orcid.org/0000-0003-0594-0360)
- Jessica Haines (ORCID: https://orcid.org/0009-0003-2535-4825)
- James Downar (ORCID: https://orcid.org/0000-0001-7479-1560)
- Lisa D. Burry (ORCID: https://orcid.org/0000-0002-6545-3890)
- Irene Watpool (ORCID: https://orcid.org/0000-0001-7211-9586)
- Alison Fox-Robichaud
- Nadia Polskaia
Institutions
- University of Ottawa (CA)
- Ottawa Hospital (CA)
- Sinai Health System (CA)
- Bruyère (CA)
- Ottawa Hospital Research Institute (CA)
- Hamilton Health Sciences (CA)
- McMaster University (CA)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1097/ccm.0000000000006534
- Citations
- 9
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 13.91
Funders
- Hamilton Health Sciences
- McMaster University
- Canadian Institutes of Health Research