Towards precision medicine strategies using plasma proteomic profiling for suspected gallbladder cancer: A pilot study

This study highlights the potential of plasma proteomic profiling to significantly improve the preoperative diagnostic accuracy of gallbladder cancer <i>vs.</i> cholecystitis. Using machine learning models, we identified biologically relevant plasma proteins associated with the diagnosis of gall bladder cancer. A noninvasive preoperative test based on selected plasma proteins could potentially enhance clinical decision-making, reduce unnecessary surgeries, and mitigate the associated risks for patients with suspected GBC, marking a step forward in precision medicine.