SPICE1 promotes osteosarcoma growth by enhancing the deubiquitination of FASN mediated by USP10
This study elucidates the role of SPICE1 as a potential oncogene in OS, highlighting its contribution to tumor growth through the modulation of FASN stability. Importantly, our results suggest that targeting the SPICE1/USP10/FASN signaling axis could offer a novel therapeutic approach for treating OS. Future investigations should focus on the development of specific inhibitors that disrupt this pathway, ultimately leading to improved clinical outcomes for patients with OS.
Authors
- Weilai Tong
- Zhili Liu (ORCID: https://orcid.org/0000-0003-2359-5142)
- Jiangbo Nie (ORCID: https://orcid.org/0000-0002-5639-8324)
- Xinsheng Xie (ORCID: https://orcid.org/0009-0002-3186-8964)
- Feng Yang (ORCID: https://orcid.org/0000-0001-7190-4064)
- Jiaming Liu (ORCID: https://orcid.org/0000-0001-8444-9136)
- Zhiguo Shu
- Xianhe Yang
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial People's Hospital (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s12967-025-06248-1
- Citations
- 2
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province