Cervical cerclage versus cervical pessary with or without vaginal progesterone for preterm birth prevention in twin pregnancies and a short cervix: A two-by-two factorial randomised clinical trial
In this prematurely halted study on pregnant women with twins and a CL ≤28 mm, cerclage and cervical pessary were comparably effective on PTB <34 weeks prevention. However, compared to pessary, cerclage was associated with significantly lower rates of PTB <28 weeks and perinatal mortality. ClinicalTrials.gov Registration: NCT03863613 (https://clinicaltrials.gov/study/NCT03863613).
Authors
- Lan N. Vuong (ORCID: https://orcid.org/0000-0001-6529-6912)
- Cam H. Le
- Thanh Nhã Yến Hê (ORCID: https://orcid.org/0000-0001-8864-7682)
- Vinh Q. Dang (ORCID: https://orcid.org/0000-0001-5205-8210)
- Trung Q. Bui (ORCID: https://orcid.org/0009-0001-4961-6602)
- Ha N. H. Pham
- Nhu T. Vuong
- Lê Văn Thành (ORCID: https://orcid.org/0000-0002-7757-1042)
- Tri Nguyen (ORCID: https://orcid.org/0000-0003-0670-0414)
- Ben W. Mol (ORCID: https://orcid.org/0000-0001-8337-550X)
- Wentao Li (ORCID: https://orcid.org/0000-0001-8980-0909)
- Tuong Manh Ho (ORCID: https://orcid.org/0000-0003-3528-7358)
- Diem Nguyen (ORCID: https://orcid.org/0009-0009-9629-2004)
Institutions
- University of Medicine and Pharmacy at Ho Chi Minh City (VN)
- UNSW Sydney (AU)
- National Centre for Clinical Research on Emerging Drugs (AU)
- Amsterdam University Medical Centers (NL)
- Viet Duc Hospital (VN)
- Monash University (AU)
- University of Amsterdam (NL)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1371/journal.pmed.1004526
- Citations
- 4
- Primary Topic
- Preterm Birth and Chorioamnionitis
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Norgine
- National Health and Medical Research Council