The vasoconstrictor adenosine 5′-tetraphosphate is a danger signal that induces IL-1β
Collectively, our findings suggest Ap4 as a novel pro-inflammatory mediator capable of inducing IL-1β release in innate immune cells through distinct mechanisms from classical NLRP3 inflammasome activators, shedding light on its potential role in inflammatory diseases and vascular disorders.
Authors
- Jonas Engelhardt
- Günther Weindl (ORCID: https://orcid.org/0000-0002-4493-7597)
- Markus Tölle (ORCID: https://orcid.org/0000-0001-9843-2132)
- Judith Bockstiegel
- Mirjam Schuchardt
Institutions
- University of Bonn (DE)
- Humboldt-Universität zu Berlin (DE)
- MSB Medical School Berlin (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s10020-025-01116-6
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Rheinische Friedrich-Wilhelms-Universität Bonn