Adipose tissue deficiency impairs transient lipid accumulation and delays liver regeneration following partial hepatectomy in male Seipin knockout mice
Seipin<sup>-/-</sup> mice, which lack adipose tissue, exhibit significantly impaired TRAS and delayed liver regeneration following partial hepatectomy. Transplantation of normal adipose tissue into Seipin<sup>-/-</sup> mice restores TRAS and enhances liver regeneration, highlighting the essential role of adipose tissue in these processes. Liver-specific overexpression of Seipin has no effect on TRAS and liver regeneration in Seipin<sup>-/-</sup> mice.
Authors
- Mingming Gao (ORCID: https://orcid.org/0000-0002-0589-7633)
- Hongyuan Yang (ORCID: https://orcid.org/0000-0002-8482-6031)
- Xiaoqin Wu (ORCID: https://orcid.org/0000-0002-0409-8119)
- Kexin Ma (ORCID: https://orcid.org/0009-0005-7864-0416)
- Yaru Zhou (ORCID: https://orcid.org/0000-0002-9067-4361)
- Yang Liu (ORCID: https://orcid.org/0000-0002-4363-0198)
- Xin Chen (ORCID: https://orcid.org/0000-0002-5189-5647)
- Ziwei Liu (ORCID: https://orcid.org/0000-0002-1812-2538)
- Xiaowei Wang (ORCID: https://orcid.org/0000-0002-1986-8411)
- Mengyu Wang (ORCID: https://orcid.org/0000-0002-7188-7126)
- Qianqian Dong (ORCID: https://orcid.org/0000-0002-6001-4872)
- Jiyou Tang (ORCID: https://orcid.org/0000-0002-4520-6585)
- Yidan Ma (ORCID: https://orcid.org/0000-0002-2693-8115)
- Chenxi Liang (ORCID: https://orcid.org/0000-0003-1175-6252)
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Bethune International Peace Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/ctm2.70238
- Citations
- 4
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 5.29
Funders
- Natural Science Foundation of Hebei Province