FOXO3-induced microRNA-128-3p promotes the progression of spinal cord injury in mice via regulating NLRP3 inflammasome-mediated pyroptosis
To the best of our knowledge, this is the first report demonstrating miR-128-3p improved secondary injury in SCI through the modulation of cell pyroptosis pathway. Our results suggest that FOXO3/miR-128-3p/TXNIP/NLRP3-mediated pyroptosis axis may be a potential therapeutic target for SCI.
Authors
- Yunzhi Guan
- Xinlei Xia (ORCID: https://orcid.org/0000-0002-3761-5004)
- Jianyuan Jiang (ORCID: https://orcid.org/0000-0001-6876-7820)
- Shuo Yang (ORCID: https://orcid.org/0000-0003-4835-9971)
- Chaojun Zheng
- Xiaosheng Ma (ORCID: https://orcid.org/0000-0003-2979-0870)
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1526721
- Citations
- 4
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.22