Genetic variation in RYR1 is associated with heart failure progression and mortality in a diverse patient population
Increased <i>RYR1</i> expression may contribute to HF progression, potentially through the mechanisms associated with calcium handling and arrhythmia development. Our findings suggest that <i>RYR1</i> should be further studied as a potential therapeutic target for reducing HF-related mortality.
Authors
- Yimei Huang (ORCID: https://orcid.org/0000-0002-2011-4844)
- Brian E. Gawronski (ORCID: https://orcid.org/0009-0000-9513-4244)
- Julio D. Duarte (ORCID: https://orcid.org/0000-0001-9766-4038)
- Christelle Lteif (ORCID: https://orcid.org/0000-0002-0468-8936)
- Leonardo A. Guerra (ORCID: https://orcid.org/0000-0001-7385-7337)
- Arthur Renan Fernandes Nogueira (ORCID: https://orcid.org/0009-0008-3553-7445)
- Rylie M. Flohr
Institutions
- UF Health Shands Hospital (US)
- University of Florida (US)
- Florida College (US)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-02-21
- DOI
- https://doi.org/10.3389/fcvm.2025.1529114
- Citations
- 3
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.42