Association between the use of proton pump inhibitors and serum PSA levels in the general U.S. population
Contrary to the available data in the context of PCa, we found no evidence of increased PSA levels in PPI users with no prostate malignancy. Instead, PPI use was associated with a decrease of total PSA in older adults. This adds knowledge on how PPIs may influence PSA in population-based screening programs.
Authors
- Mirko Parasiliti‐Caprino (ORCID: https://orcid.org/0000-0002-6930-7073)
- Iacopo Gesmundo (ORCID: https://orcid.org/0000-0003-4901-4764)
- Ezio Ghigo
- Marco Oderda
- Luigi Simone Aversa
- Riccarda Granata (ORCID: https://orcid.org/0000-0003-4164-7313)
- Paolo Gontero (ORCID: https://orcid.org/0000-0002-9714-6596)
- Giorgio Calleris (ORCID: https://orcid.org/0000-0003-3831-1632)
- Fabio Bioletto (ORCID: https://orcid.org/0000-0001-7550-7023)
- Giancarlo Marra (ORCID: https://orcid.org/0000-0003-1080-4320)
Institutions
- Department of Medical Sciences (BY)
- University of Turin (IT)
Publication Details
- Journal
- World Journal of Urology
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1007/s00345-025-05469-9
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Torino