Subepicardial adipose genes contribute to the deterioration of heart failure preserved ejection fraction
The screened hub genes, including OGN, FOS and ALOX5, were validated using single-cell sequencing data, cell lines and human samples, which can be therapeutic targets for the treatment to cell senescence under hypoxia and prediction to heart failure progression to HFpEF.
Authors
- Jiaqi Zhang (ORCID: https://orcid.org/0009-0008-2107-163X)
- Yuheng Lang
- Yue Zheng (ORCID: https://orcid.org/0000-0002-6281-5163)
- Zheng Han (ORCID: https://orcid.org/0000-0003-1537-3822)
- Yu‐Chao Wang (ORCID: https://orcid.org/0000-0002-1574-1691)
- Bingyang Zhou
- Ruiying Zhang (ORCID: https://orcid.org/0000-0002-6597-1495)
- Man Wang (ORCID: https://orcid.org/0000-0002-6248-670X)
Institutions
- Tianjin University (CN)
- Nankai University (CN)
- Tianjin Third Central Hospital (CN)
- Tianjin Chest Hospital (CN)
- Center for Life Sciences (CN)
- Tianjin Medical University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-02-21
- DOI
- https://doi.org/10.3389/fcvm.2025.1501397
- Citations
- 1
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 1.39