Detection of hemodynamic changes in a porcine lipopolysaccharide model of systemic inflammation using dynamic light scattering measurements of the microcirculation
Changes in microcirculatory parameters, relHIs, and the Hurst exponent, were recorded for 3 h following LPS administration. The Hurst exponent was significantly lower in the LPS and LPS with resuscitation groups than in controls. Further clinical studies are required to determine the sensitivity and specificity of the non-invasive mDLS™ sensor for sepsis detection.
Authors
- Louwrina H. te Nijenhuis (ORCID: https://orcid.org/0000-0001-5094-2512)
- Willem van Weteringen (ORCID: https://orcid.org/0000-0003-2667-3169)
- Norani H. Gangaram-Panday (ORCID: https://orcid.org/0000-0002-6034-4425)
- Irwin Reiss (ORCID: https://orcid.org/0000-0002-9474-6895)
- Egbert G. Mik (ORCID: https://orcid.org/0000-0001-8191-2236)
- Ilya Fine (ORCID: https://orcid.org/0000-0002-3237-1581)
- Patricia A. C. Specht (ORCID: https://orcid.org/0000-0002-6421-3035)
- Floor A. Harms (ORCID: https://orcid.org/0000-0002-5478-4993)
- Nimrod Elstein
Institutions
- Elfi-Tech (Israel) (IL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Rotterdam University of Applied Sciences (NL)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-02-21
- DOI
- https://doi.org/10.3389/fmed.2025.1522630
- Citations
- 1
- Primary Topic
- Thermoregulation and physiological responses
- Type
- article
- Field-Weighted Citation Impact
- 1.16