Impaired immune reconstitution in HIV infection: the role of CD4+ T-cell-associated NKG2D ligands, CD4+ T-cell subsets imbalance, and immune function deficiency
The upregulation of related ligands for the NKG2D receptor on CD4<sup>+</sup> T cells in INRs is associated with increased susceptibility of CD4<sup>+</sup> T cells to NK cell-mediated killing. CD95 may plays an important role in poor recovery of CD4<sup>+</sup> T cells co-expressing NKG2D-related ligands. The imbalance in CD4<sup>+</sup> Tcm and CD4<sup>+</sup> Temra subset homeostasis and impaired CD31 expression on naive CD4<sup>+</sup> T cells in INRs are associated with poor immune reconstitution outcomes.
Authors
- Tong Zhang (ORCID: https://orcid.org/0000-0002-9657-5129)
- Peng Xu (ORCID: https://orcid.org/0000-0003-0822-700X)
- Qianqian Xu (ORCID: https://orcid.org/0000-0003-1393-6644)
- Christiane Moog (ORCID: https://orcid.org/0000-0002-0916-156X)
- Xin Zhang (ORCID: https://orcid.org/0000-0001-9751-7054)
- Hao Wu (ORCID: https://orcid.org/0000-0003-3083-2345)
- Bin Su (ORCID: https://orcid.org/0000-0001-5140-0440)
- Qiuyue Zhang (ORCID: https://orcid.org/0009-0007-3544-1323)
Institutions
- Inserm (FR)
- Capital Medical University (CN)
- Beijing YouAn Hospital (CN)
- Shenzhen Third People’s Hospital (CN)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1541574
- Citations
- 4
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- National Natural Science Foundation of China
- Capital Medical University
- Beijing Municipal Health Commission