Sex-dependent alterations of colonic epithelial permeability: relevance to irritable bowel syndrome
Our study confirms prior reports that IBS patients demonstrate altered sigmoid colonic epithelial function and shows for the first time that these are independent of sex. However, sex differences in sigmoid colonic epithelial function are observed independently of disease status. Further studies are needed to delineate if intestinal permeability interacts with other factors in the pathophysiology of IBS and if these interactions differ by sex.
Authors
- Muriel Larauche (ORCID: https://orcid.org/0000-0003-3320-3675)
- Emeran A. Mayer (ORCID: https://orcid.org/0000-0003-3923-3349)
- Lin Chang (ORCID: https://orcid.org/0000-0001-6800-2967)
- Mandy Biraud
- Swapna Mahurkar‐Joshi (ORCID: https://orcid.org/0000-0001-9591-4590)
- Tiffany Ju
Institutions
- University of California, Los Angeles (US)
- VA Greater Los Angeles Healthcare System (US)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-02-21
- DOI
- https://doi.org/10.3389/fphys.2025.1509935
- Citations
- 6
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 10.87
Funders
- UCLA Health System