Elucidation of Callistemon lanceolatus-derived natural compounds in STAT 3 pathway against human cancer cells: in silico and in vitro studies
It is revealed through results that active components in these compounds inhibited cancer cell migration and invasion and suppressed the proliferation of noncancer cells. Moreover, these natural compounds from <i>C. lanceolatus</i> downregulated the expression of STAT3 downstream target proteins, indicating their potential as therapeutic agents against cancer. Thus, cyanidin-3,5-diglucoside, kaempferol-3-o-β-d-galactopyranoside, and quercetin-3-o-(2″-o-galloyl)-β-d-galactopyranoside from <i>C. lanceolatus</i> are promising candidates for cancer treatment.
Authors
- Sadaf Anwar (ORCID: https://orcid.org/0000-0001-8153-2321)
- Naveed Iqbal (ORCID: https://orcid.org/0000-0001-7261-3357)
- Mohd Adnan Kausar (ORCID: https://orcid.org/0000-0002-8931-9290)
- Mohammad Zeeshan Najm (ORCID: https://orcid.org/0000-0002-0464-9152)
- Mubashir Zafar (ORCID: https://orcid.org/0000-0002-7440-0635)
- Abrar Ali (ORCID: https://orcid.org/0000-0002-0563-3742)
- Malik Asif Hussain
- Sadaf Sadaf
Institutions
- Apeejay Stya University (IN)
- Department of Biotechnology (IN)
- University of Ha'il (SA)
- Jamia Millia Islamia (IN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-21
- DOI
- https://doi.org/10.3389/fphar.2025.1507002
- Citations
- 2
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- University of Hail