Exploration the therapeutic effects of sodium houttuyfonate combined with penicillin G on methicillin resistant staphylococcus aureus infected wounds
Sodium houttuyfonate combined with penicillin G can inhibit bacterial growth in MRSA infected wounds in rats, reduce neutrophil infiltration, promote collagen fiber generation in wounds, and decrease the expression levels of inflammatory factors IL-6 and TNF-α in the blood of rats after MRSA infection. It promotes wound healing through multiple targets and pathways, and preliminarily reveals the drug's targets and molecular mechanisms.
Authors
- Yan Cai (ORCID: https://orcid.org/0000-0002-4768-0272)
- Xudong Xiang (ORCID: https://orcid.org/0009-0000-4565-4778)
- Shunjie You
- Si Li (ORCID: https://orcid.org/0000-0001-7997-0904)
- Yujie Li (ORCID: https://orcid.org/0000-0002-9413-096X)
- Sheng Li (ORCID: https://orcid.org/0000-0003-1401-0923)
- Shen Shi
- Anqi Jia (ORCID: https://orcid.org/0009-0003-1321-6441)
Institutions
- Leshan Normal University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-21
- DOI
- https://doi.org/10.3389/fphar.2025.1530217
- Citations
- 2
- Primary Topic
- Nephrotoxicity and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Health Commission of Sichuan Province
- Bijzonder Onderzoeksfonds UGent