Global Myocardial Work Index Predicts Response to Biventricular Pacing in Patients with Non-Left Bundle Branch Block

High GWI assessed by speckle-tracking echocardiography and a non-invasively estimated LV pressure curve was independently associated with a favourable response to CRT and improved outcomes in patients with non-LBBB. The use of this non-invasive approach for quantifying myocardial variability and residual contractility can be beneficial for assessing CRT candidates and allow for more accurate patient stratification. Further, large multicentre studies are required to validate these findings.