Cold-induced anaphylaxis: new insights into clinical and genetic characteristics
This study confirmed clinical features linked to ColdA previously identified by the multicenter COLD-CE study, including generalized wheals, skin angioedema, oropharyngeal/laryngeal manifestations, and itchy earlobes. We identified new high-risk features. ColdA is more frequently associated with typical ColdU than with ColdU with negative sCST, the latter being linked to spontaneous wheals. ColdA is additionally associated with higher total IgE levels. Furthermore, patients with ColdU and ColdA exhibit higher prevalence of <i>KIT</i> p.D816V and HαT compared to general population data, a finding not previously reported. Further research is needed to explore their clinical implications.
Authors
- Urška Bidovec‐Stojkovič (ORCID: https://orcid.org/0000-0001-8978-6887)
- Julij Šelb (ORCID: https://orcid.org/0000-0001-9499-6504)
- Mojca Bizjak (ORCID: https://orcid.org/0000-0003-2595-468X)
- Matija Rijavec (ORCID: https://orcid.org/0000-0002-2596-4952)
- Peter Korošec (ORCID: https://orcid.org/0000-0002-0835-1599)
- Samo Zver
- Mitja Košnik (ORCID: https://orcid.org/0000-0002-4701-7374)
- Dejan Dinevski (ORCID: https://orcid.org/0000-0001-5285-2246)
- Manca Svetina
Institutions
- University of Ljubljana (SI)
- Ljubljana University Medical Centre (SI)
- University of Maribor (SI)
- University Clinic of Pulmonary and Allergic Diseases Golnik (SI)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1558284
- Citations
- 6
- Primary Topic
- Food Allergy and Anaphylaxis Research
- Type
- article
- Field-Weighted Citation Impact
- 9.73
Funders
- Javna Agencija za Raziskovalno Dejavnost RS