Therapeutic potential of miR-133a-transfected bone marrow mesenchymal stem cell transplantation in improving cardiac function post-myocardial infarction
Our results demonstrate that miR-133a transfection following MI improves the survival rate of transplanted MSCs in ischemia-hypoxic myocardium, inhibits the transformation of cardiac fibroblasts into myofibroblasts, reduces myocardial fibrosis, and improves cardiac function following MI. This approach holds promise as a novel therapeutic strategy for myocardial repair.
Authors
- Yongyong Shi (ORCID: https://orcid.org/0000-0003-1710-1505)
- Biao Cheng (ORCID: https://orcid.org/0000-0003-3383-1671)
- Minghuan Fu
- Jie Gao (ORCID: https://orcid.org/0000-0002-6186-2750)
- Wei Zhang
- Xiaohan Chen (ORCID: https://orcid.org/0000-0001-5326-7743)
- Xuefei Tao (ORCID: https://orcid.org/0000-0001-9714-709X)
- Yongjun Cao (ORCID: https://orcid.org/0000-0002-8135-8914)
Institutions
- University of Electronic Science and Technology of China (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Journal of Cardiothoracic Surgery
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s13019-025-03367-0
- Citations
- 1
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 1.63